Metronidazole is the major component appearing in the plasma, with lesser quantities of metabolites also being present. Less than 20% of the circulating metronidazole is bound to plasma proteins. Metronidazole appears in cerebrospinal fluid, saliva, and breast milk in concentrations similar to those found in plasma.
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Metronidazole may cause serious side effects including: Nervous system problems, including brain disorder (encephalopathy), inflammation of the brain and spinal cord membranes (aseptic meningitis), numbness or tingling in the hands or feet (peripheral neuropathy), and seizures (convulsions).
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Metronidazole has been shown to cause cancer in mice and rats with long-term use. Talk with the doctor. The doctor has given you this medicine (metronidazole tablets and capsules) for a certain health problem. Do not use this medicine (metronidazole tablets and capsules) for other health problems.
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Detailed Metronidazole dosage information for adults and children. Includes dosages for Bacterial Infection, Skin or Soft Tissue Infection, Skin and Structure Infection and more; plus renal, liver and dialysis adjustments.
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Metronidazole can cause life-threatening liver problems in people with Cockayne syndrome. If you have this condition, stop taking Flagyl and contact your doctor if you have signs of liver failure --nausea, stomach pain (upper right side), dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
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Metronidazole tablets belong to a group of medicines called anti-infective agents. They may be used to treat: infections, caused by bacteria of the blood, brain, bone, lung, stomach lining and pelvic area, following childbirth or in a wound following an operation. urinary or genital infections caused by a parasite, Trichomonas.
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Metronidazole is an antibiotic that is particularly effective at treating infections caused by susceptible anaerobic bacteria and parasites. Alcohol and products containing propylene glycol should be avoided while taking metronidazole and for three days after stopping it.
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Applies to metronidazole: compounding powder, intravenous powder for injection, intravenous solution, oral capsule, oral suspension, oral tablet, oral tablet extended release. General The most serious side effects reported were convulsive seizures, encephalopathy , aseptic meningitis, optic neuropathy, and peripheral neuropathy (characterized by numbness/paresthesia of an extremity).
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Metronidazole Interactions. There are 354 drugs known to interact with metronidazole, along with 7 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 13 are major, 337 are moderate, and 4 are minor.
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Amebiasis. Treatment of acute intestinal amebiasis and amebic liver abscess caused by Entamoeba histolytica. Oral metronidazole or oral tinidazole followed by a luminal amebicide (iodoquinol, paromomycin) is the regimen of choice for mild to moderate or severe intestinal disease and for amebic hepatic abscess.
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